Premarin Conjugated Oestrogen Cream relieves moderate to severe painful intercourse caused by menopausal changes. Unlike over-the-counter treatments, it works by delivering estrogens directly to the source of the pain. Therefore, it helps rebuild vaginal tissue and make intercourse more comfortable. With Premarin Vaginal Cream, you’re not taking a hormone pill. You simply apply a blueberry-sized dose with a special applicator directly to the affected area.