Lortan 50mg Tablets 30’s contains losartan and hydrochlorothiazide which treat high blood pressure. Losartan works by blocking the hormone angiotensin thereby relaxing blood vessels. Also, it allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.