Description
Irifone Gel 5% 50g is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
Indications/Uses: Relief of rheumatic and muscular pain as a 5% gel or 10% cream
When this drug is applied simultaneously with:
- digoxin slightly increased the concentration of digoxin in plasma.
- itraconazole greatly increases the concentration of atorvastatin in plasma, apparently due to inhibition of itraconazole its metabolism in the liver that occurs with the participation of isoenzyme CYP3A4; increased risk of myopathy.
- colestipol may decrease the concentration of atorvastatin in plasma, with lipid-lowering effect is enhanced.
- antacids containing magnesium hydroxide and aluminum hydroxide, reduce the concentration of atorvastatin by approximately 35%.
- cyclosporine, fibrates (including gemfibrozil), azole antifungals derivatives, nicotinic acid increases the risk of myopathy.
Side effects include :
Digestive system: nausea, vomiting, steroid ulcer, and duodenal ulcer, esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, hiccups.
Metabolism: the negative nitrogen balance due to protein catabolism, hypocalcemia, weight gain, increased sweating.
